Artesunate injection 80mg

artesunate injection
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Product Description

Contains:

Artesunate 20mg/40mg/60mg/80mg vial

Package

40mg per vial with Sodium bicarbonate solution+Water for injection in box
60mg per vial with Sodium bicarbonate solution+Water for injection in box
80mg per vial with Sodium bicarbonate solution+Water for injection in box

Indications

Treatment of severe malaria
Initial treatment of uncomplicated malaria, when persistent vomiting precludes oral therapy

Forms and strengths, route of administration

Powder for injection, in 60 mg-vial, with one 1 ml-ampoule of 5% sodium bicarbonate and one 5 mlampoule of 0.9% sodium chloride, for slow IV injection (3 to 5 minutes) or slow IM injection. NEVER ADMINISTER BY IV INFUSION.
Dissolve the powder in the entire volume of 5% sodium bicarbonate and shake the vial until the solution becomes clear. Then, add the 0.9% sodium chloride into the vial:
5 ml of 0.9% sodium chloride to obtain 6 ml of artesunate solution containing 10 mg/ml, for IV injection
2 ml of 0.9% sodium chloride to obtain 3 ml of artesunate solution containing 20 mg/ml, for IM injection

Dosage and duration

Child under 20 kg: 3 mg/kg/dose
Child 20 kg and over and adult: 2.4 mg/kg/dose

One dose on admission (H0) then 12 hours after admission (H12) then 24 hours after admission (H24) then, once daily.
Administer parenterally at least 24 hours (3 doses), then, if the patient can tolerate the oral route, change to a complete 3-day course of an artemisinin-based combination. If not, continue parenteral treatment once daily until the patient can change to oral route (without exceeding 7 days of parenteral treatment).

WeightIV injection

artesunate solution 10 mg/ml

IM injection

artesunate solution 20 mg/ml

3 kg1 ml0.5 ml (a)
3 to < 4 kg1.2 ml0.6 ml (a)
4 to < 5 kg1.5 ml0.8 ml (a)
5 to < 6 kg2 ml1 ml
6 to < 8 kg2.5 ml1.2 ml
8 to < 10 kg3 ml1.5 ml
10 to < 13 kg4 ml2 ml
13 to < 15 kg4.5 ml2.5 ml
15 to < 17 kg5 ml2.5 ml
17 to < 20 kg6 ml3 ml
20 to < 25 kg6 ml3 ml
25 to < 29 kg (b)7 ml3.5 ml
29 to < 33 kg8 ml4 ml
33 to < 37 kg9 ml5 ml
37 to < 41 kg10 ml5 ml
41 to < 45 kg11 ml6 ml
45 to < 50 kg12 ml6 ml
50 to < 55 kg (b)13 ml7 ml
55 to < 62 kg15 ml8 ml
62 to < 67 kg16 ml8 ml
67 to < 71 kg17 ml9 ml
71 to < 76 kg18 ml9 ml
76 to 81 kg (b)20 ml10 ml
  • (a)Use a 1 ml syringe graduated in 0.01 ml when the dose required is less than 1 ml.
  • (b)For patients over 25 kg, a 2nd vial must be prepared to obtain the volume needed, a 3rd vial for patients over 50 kg and a 4th vial for patients over 76 kg.